I’ve been playing a bit of Resident Evil 4 on the Wii, and it’s amazing – not the game so much as using the Wiimote to play it. What is (so far) a pretty standard O Noes! Zombies! game becomes considerably scarier and more stressful when you’re trying to aim your gun for real or stab someone with the Wiimote.
It also freaks out the dog if you’re playing it on headphones.